By Jennifer L. Hunt
The previous twenty years have noticeable an ever-accelerating progress in wisdom approximately molecular pathology of human illnesses which bought a wide advance with the sequencing of the human genome in 2003. Molecular diagnostics, molecular distinct remedy and genetic remedy are actually regimen in lots of clinical facilities. The molecular box now affects each box in medication, even if scientific learn or regimen sufferer care. there's a nice want for uncomplicated researchers to appreciate the capability scientific implications in their examine while deepest perform clinicians of all kinds (general inner drugs and inner medication experts, scientific oncologists, radiation oncologists, surgeons, pediatricians, family members practice), scientific investigators, pathologists and clinical laboratory administrators and radiologists require a simple realizing of the basics of molecular pathogenesis, prognosis and therapy for his or her sufferers. conventional textbooks in molecular biology take care of uncomplicated technological know-how and aren't with ease appropriate to the clinical atmosphere. so much scientific textbooks that come with a point out of molecular pathology within the medical surroundings are restricted in scope and suppose that the reader already has a operating wisdom of the elemental technology of molecular biology. different texts emphasize expertise and trying out techniques with no integrating the scientific point of view. there's an pressing want for a textual content that fills the space among simple technology books and scientific perform. within the Molecular Pathology Library sequence the fundamental technology and the know-how is built-in with the clinical point of view and medical program. each one e-book within the sequence is split in accordance with neoplastic and non-neoplastic illnesses for every of the organ platforms frequently linked to clinical subspecialties. each one publication within the sequence is geared up to supply (1) a succinct heritage of the fundamental terminology, options and expertise of molecular biology, (2) an summary of the extensive software of molecular biology ideas to affliction and (3) particular software of molecular pathology to the pathogenesis, prognosis and therapy of neoplastic and non-neoplastic ailments particular to every organ method. those vast part subject matters may be damaged down into succinct chapters, averaging approximately 15 to twenty pages each one, to hide a really particular illness entity. The chapters could be written by way of proven specialists at the particular subject from educational facilities around the globe. in a single ebook, different topics are incorporated that the reader must pursue from a number of assets in an effort to have a transparent realizing of the molecular pathogenesis, prognosis and therapy of particular illnesses. trying to hunt for the whole details from simple thought to express functions for a affliction from the numerous resources is time-consuming and problematical. by means of supplying this quickly and undemanding reference, figuring out and alertness of this speedily becoming box is made extra available to either specialist and generalist alike. As books that bridge the space among uncomplicated technology and scientific figuring out and perform, the Molecular Pathology sequence serves the elemental scientist, the scientific researcher and the practising general practitioner or different general practitioner who require extra realizing of the appliance of easy study to sufferer care, from "bench to bedside." This sequence is exclusive and a useful source. those books can be necessary to physicians and health and wellbeing care companies in a number of disciplines as famous above, to citizens and fellows in those a number of disciplines in addition to their instructing associations and to researchers who more and more needs to justify the medical implications in their learn.
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Additional resources for Molecular Pathology of Endocrine Diseases, Volume 3 (Molecular Pathology Library)
Montagut C, Rovira A, Albanell J. The proteasome: a novel target for anticancer therapy. Clin Transl Oncol. 2006;8(5): 313–317. Conticello C, Adamo L, Giuffrida R, et al. Proteasome inhibitors synergize with tumor necrosis factor-related apoptosis-induced ligand to induce anaplastic thyroid carcinoma cell death. J Clin Endocrinol Metab. 2007;92(5):1938–1942. Namba H, Saenko V, Yamashita S. Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer.
17 Furthermore, He et al showed that downregulation of Kit protein correlated with strong overexpression of microRNA-221, microRNA-222, and microRNA-146b. Sequencing of microRNA-221 and microRNA-222 binding domains in KIT 3¢-UTR revealed 3169G → A single nucleotide polymorphism (SNP) within microRNA-221 and microRNA-222 recognition sites. Heterozygosity for 3169G → A leads to modification in microRNA:target messenger RNA duplex conformation and decrease in efficiency of microRNA mediated C-kit translational inhibition.
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