Brain Imaging in Substance Abuse: Research, Clinical, and by Marc J. Kaufman

By Marc J. Kaufman

Hugely skilled scientific researchers from diversified fields describe intimately using electroencephalography, emission tomography, magnetic resonance imaging, and neuropsychology to check the neural results of substance abuse. They broadly evaluate learn findings those robust equipment have yielded. The authors aspect the results of gear, together with alcohol, benzodiazepines, marijuana, opiates, cocaine, amphetamines, hallucinogens, and solvents on mind electric task, metabolism, hemodynamics, receptor and neurotransmitter degrees, neurochemistry, and constitution. The remarkable findings they record emerge from greater than 1350 articles in a few 320 journals, and are geared up via technique, abused substance, and drug use nation. finished and effectively obtainable, mind Imaging in Substance Abuse: examine, scientific, and Forensic functions bargains psychiatrists, radiologists, neurologists, pharmacologists, physiologists, substance abuse experts, and lawyers a wide but completely built-in figuring out of the equipment and effects got with medical neuroimaging reports of substance abuse this day.

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Extra info for Brain Imaging in Substance Abuse: Research, Clinical, and Forensic Applications (Forensic Science and Medicine)

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G. and Himwich, H. , An electroencephalographic and chemical re-evaluation of the central action of reserpine in the rabbit. J. Pharmacol. Exp. Ther. 144:37–44, 1963. , Plas, R. , Etude comparatrive des effets neurophysiologiques du Librium et du Valium. Cl. Soc. Biol. (Paris). 157:2015–2019, 1963. Roth, W. , Late event-related potentials and psychopathology. Schizophrenia Bull. 3:105–120, 1977. Roth, W. , Tinklenberg, J. R. and Kopell, B. , Ethanol and marihuana effects on eventrelated potentials in a memory retrieval paradigm.

1995), as well as marihuana and cocaine together (Lukas, 1991). This example illustrates the importance of using EEG and behavioral measures of drug effects concurrently. Measures of Tolerance and Dependence Tolerance can be described as a diminished response to a drug with repeated exposure. It can be quantified electrophysiologically by measuring the degree to which EEG changes seen after acute administration are attenuated with repeated exposure. Power spectral analyses are usually employed to quantify the drug-induced changes in amplitude and/or frequency seen after chronic administration.

The source of the activity being measured. The frequency spectrum of the EEG ranges from 1 to 70 Hz, and usually separates into four basic categories known as alpha, beta, theta, and delta. The alpha band comprises electrical activity in the range of 8–13 Hz. Alpha activity is normally seen when the subject is awake, relaxed, and with the eyes closed. Its amplitude is usually below 50 µV, but it can range from 5 to 100 µV. These waves are also referred to as 8 Kouri and Lukas Fig. 4. Diagrammatic representation of the generation of power spectra from analog EEG waveforms.

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