Analytical Profiles of Drug Substances and Excipients, Vol. by Harry G. Brittain

By Harry G. Brittain

Even though the professional compendia outline a drug substance as to identification, purity, power, and caliber, they generally don't offer different actual or chemical facts, nor do they checklist tools of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered through the clinical literature and the records of pharmaceutical laboratories. Analytical Profiles of Drug elements and Excipients, brings the newest details jointly in a single source.•Represents an important contribution to the perform of pharmaceutical research• offers a superb evaluation of actual, chemical, and biomedical homes of a few usually prescription drugs• every one quantity within the sequence features a cumulative index

Show description

Read or Download Analytical Profiles of Drug Substances and Excipients, Vol. 29 PDF

Similar pharmacy books

Enantiomer Separation: Fundamentals and Practical Methods

Many very important pharmaceutical medications, chemical substances for the natural synthesis of chiral compounds, digital components corresponding to liquid crystals, and polymeric fabrics are chiral (enantiomeric). the improvement of recent sensible tools for the guidance of enantiomerically natural components is therefore important.

Neuropeptide Y and Drug Development

Neuropeptide Y (NPY) is a ubiquitous and demanding messenger within the apprehensive method, with quite a lot of physiological roles. it's considering the physique strength stability and is without doubt one of the such a lot effective stimuli of meals consumption recognized. NPY additionally acts to manage imperative and peripheral autonomic services. This publication, written via educational and business specialists within the box, hyperlinks the newest uncomplicated experimental wisdom approximately NPY and its receptors with parts of scientific value.

Modified Nucleosides: in Biochemistry, Biotechnology and Medicine

Edited via one of many major using forces in the back of the field's momentous upward push in recent times, this one-stop reference is the 1st entire source to combine fresh advances. the 1st half addresses biochemical elements and purposes, the second one and 3rd components are dedicated to compounds with healing power, with the 3rd half concentrating on newly brought anticancer nucleoside medications.

Dose Optimization in Drug Development

Arguably the main tough point of drug improvement, as soon as proof-of-concept is completed for a unique mechanism, is defining the “right” dose. certainly, the query speedily expands to correct for whom? a person? A inhabitants? a particular sickness? a different demographic? The solutions can yield a dizzying array of choices.

Additional resources for Analytical Profiles of Drug Substances and Excipients, Vol. 29

Example text

22. S. W. Grant, J. Pharm. , 86, 64-71 (1997). 23. S. E. J. W. Grant, J. Pharm. , 87, 501-507 (1998). 24. M. L. Bada, J. Org. , 53, 2757-2764 (1988). 25. P. Langguth, R. P. Merkle, Pharmazie, 46, 188-192, (1991). 26. J. W. B. H. Perrin, Int. J. , 88, 189-199 (1992). 27. T. Loftsson, and J. Baldvinsdottir, Acta Pharm. , 4, 329-330, (1992). 28. D. A. Connors, Pharm. , 10, 1174-1180 (1993). 29. D. A. Connors, J Pharm. , 83, 16901696 (1994). 30. H. Mazur, J. Tox. Environ. Health, 2, 243-249 (1976).

Procedure: The assay is performed by injecting equal volumes (about 20 ~tL) of the Test Solution and the Diluted Test Solution into the HPLC system, recording the chromatograms, and measuring the peak responses. The method contains a directive that the elution of the Test solution is to be continued for twice the retention time of the aspartame peak. The sum of the responses of all the peaks in the chromatogram of the Test Solution, excluding the 5-benzyl-3,6-dioxo-2-piperazineacetic acid and aspartame peak responses, is not greater than the aspartame peak response obtained from the Diluted Test Solution.

The o~-aminoacids have been reported to form stable complexes with transition metals. The derivatives of acetic acid are particularly noteworthy for their chelating ability. The most remarkable for the acetic acid derivatives, however, is ethylenediaminetelraacetic acid (often abbreviated EDTA or I-bY). The complexes of EDTA are remarkably stable, and have been investigated extensively from the industrial point of view. The substance has been used in water softening, electmplating, controlling of metal content of dye paths, in removing lead and other heavy metals from the human systems, and in the treatment ofchlorosis in plants [7].

Download PDF sample

Rated 4.86 of 5 – based on 44 votes