By Harry G. Brittain
Even though the professional compendia outline a drug substance as to identification, purity, power, and caliber, they generally don't offer different actual or chemical facts, nor do they checklist tools of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered through the clinical literature and the records of pharmaceutical laboratories. Analytical Profiles of Drug elements and Excipients, brings the newest details jointly in a single source.•Represents an important contribution to the perform of pharmaceutical research• offers a superb evaluation of actual, chemical, and biomedical homes of a few usually prescription drugs• every one quantity within the sequence features a cumulative index
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Additional resources for Analytical Profiles of Drug Substances and Excipients, Vol. 29
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Procedure: The assay is performed by injecting equal volumes (about 20 ~tL) of the Test Solution and the Diluted Test Solution into the HPLC system, recording the chromatograms, and measuring the peak responses. The method contains a directive that the elution of the Test solution is to be continued for twice the retention time of the aspartame peak. The sum of the responses of all the peaks in the chromatogram of the Test Solution, excluding the 5-benzyl-3,6-dioxo-2-piperazineacetic acid and aspartame peak responses, is not greater than the aspartame peak response obtained from the Diluted Test Solution.
The o~-aminoacids have been reported to form stable complexes with transition metals. The derivatives of acetic acid are particularly noteworthy for their chelating ability. The most remarkable for the acetic acid derivatives, however, is ethylenediaminetelraacetic acid (often abbreviated EDTA or I-bY). The complexes of EDTA are remarkably stable, and have been investigated extensively from the industrial point of view. The substance has been used in water softening, electmplating, controlling of metal content of dye paths, in removing lead and other heavy metals from the human systems, and in the treatment ofchlorosis in plants .