A Multidisciplinary Approach to Myelin Diseases by D. R. Colman, L. Bernier, J. L. Salzer, S. Gillespie, P.

By D. R. Colman, L. Bernier, J. L. Salzer, S. Gillespie, P. Brophy, D. D. Sabatini (auth.), G. Serlupi Crescenzi (eds.)

The current publication relies at the papers offered in the course of an inter­ disciplinary assembly which used to be held in Rome October 27-30, 1986, on the Istituto Superiore di Sanita less than the sponsorship of NATO, and with a monetary contribution of the Cassa di Risparmio di Roma. The assembly was once of serious curiosity simply because, for the 1st time, a gaggle of hugely certified scientists focusing on various fields have been collected jointly to debate the matter of demyelinating illnesses. In thi. context molecular biologists, immunologists, virologists, and lipid chemists may well seek advice from clinicians for 4 days each point of demyelinating ailments. They shared result of the newer learn with the wish that extra wisdom of the myelinating technique will ultimately achieve discovering new remedies for those ailments. The assembly was once winning, possibly partially simply because discussions in the course of lunches and dinners supplied a chance for the alternate of latest principles. This used to be obvious within the discussions held after the presen­ tation of every paper and was once summarized within the very vigorous around desk which was once hung on the final day. The editor needs to specific his because of the clinical committee participants: N. Baumann, C. Fieschi, G. Macchi, J.M. Matthieu, ok. Suzuki. It used to be their suggestion that made the alternative of individuals and matters such a success. The organizer additionally recognize the organizing help of NATO in getting ready those court cases. Acknowledgments need to be provided to Dr. S. Salvati, Dr. A.M.

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17:109 (1986). T. Inuzuka, I. D. Duncan, and R. H. , 27:43 (1986). A. Akowitz, K. ScheId, E. Barbarese, and J. H. Soc. , 17:108 (1986). MYELIN PROTEOLIPID PROTEIN EXPRESSION IN NORMAL AND JIMPY MICE Wendy B. 2Macklin 1 , Minnett y V. Gardinier 1 ,2, Prescoit L. Deninger , Barbara A. Sorg and Celia W. Campagnoni 1. Mental Retardation Research Center, UCLA Medical Center Los Angeles, California 90024 2. , 1970). Myelin integrity is essential for normal nervous system function, and understanding the mechanism of myelin formation is important because of the large number of clinical problems observed when normal myelin formation is altered (Adams and Victor, 1970).

In the absence of the factor, myelin components would be synthesized at low basal levels which would allow the maintenance of the myelin sheath and possibly some repair. This hypothesis is supported by observations in other dysmyelinating mutants and does not seem to be restricted to a defect of MBP synthesis. For example, inappropriately high levels of MBP gene expression were reported in jimpy mice (51), where the mutation affects the proteolipid protein structural gene (52,53). Furthermore, in a canine dysmyelinating mutant (the 'shaking pup') (54) abnormalities were observed in oligodendrocytes similar to the ones we reported in mId mice with accumulation of MAG.

5ince the same probe was protected from both probes and two probes were identical at their 3' ends, but different at their 5' ends, the protected fragment was apparently in the 3' end of the probes. This would suggest that the deletion in the jimpy mRNA is not between nucleotides 825-960, and that it consists of a region ending at nucleotide 825. The data from this experiment do not provide evidence for the site of the beginning of the deletion. 32 When Southern blots of jimpy genomic DNA were probed with P-Iabeled p27, the full length rat cDNA, no alteration of the size of the DNA restriction fragments was seen relative to comparable blots of normal genomic DNA.

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